By embedding within the Pennsylvania Biotechnology Center, TherimuneX derives substantial tangible and intangible benefit from the core-competencies located at the Center. This affiliation has the direct impact of reducing our overhead cost and our capital equipment cost and, thus, allowing us to apply each dollar towards the direct advancement of our science and our lead drug candidates toward clinical use.
The laboratories of the Institute for Hepatitis and Virus Research are located at the 115,000 square-foot facility known as the Pennsylvania Biotechnology Center. The space is fully operational for modern molecular biology research. Laboratories are equipped with laminar flow hoods, table top centrifuges, ThermoFinnegan LCQ and ABI Qtrap Mass Spectrometers, Waters HPLC systems, a Biomek NX robot liquid handler, and other equipment that is routine for modern biology and drug discovery laboratories.
Core equipment at the Pennsylvania Biotechnology Center includes 4 ultracentrifuges, 3 automated programmable autoclaves, 3 liquid scintillation counters, 2 real-time thermocyclers, image analyzers for proteomics, a dark room, a clean room, a BL3 laboratory, liquid Nitrogen cryopreservation tanks, a FACS laboratory, a microscopy laboratory, and a Parr Hydrogenator for high temperature, high pressure hydrogenation reactions from 5L to 50L scale.
The Center is served by a network linked by T100-Base ethernet and secure WiFi and central network storage. There are two central offices staffed with 8 employees to handle the administrative work of the Center.
There are over 150 full-time scientists employed at the Center in multiple life science disciplines creating a diverse scientific culture and a rich cross-pollination of scientific thought. As a poigniant example, the development of our lead drug candidate as a therapeutic for the treatment of chronic Hepatitis B virus infection is a direct result of the interdisciplinary environment that exists at the Center.
Embedded within the Center, the laboratory suite for TherimuneX consists of two adjoining laboratories. One laboratory is a standard molecular biology laboratory and the other is a peptide synthesis laboratory. Both laboratories operate under cGLP requirements as specified under U.S. CFR Title 21 Part 58.
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